RapamycinFungusV1, Main, Exploration, bibRecord, 000089

Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.

Identifieur interne : 000089 ( Main/Exploration ); précédent : 000088; suivant : 000090

Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.

Auteurs : Shun-Fa Yang [Taïwan] ; Yong-Syuan Chen [Taïwan] ; Hsiang-Wen Chien [Taïwan] ; Kai Wang [Taïwan] ; Chia-Liang Lin [Taïwan] ; Hui-Ling Chiou [Taïwan] ; Chia-Yi Lee [Taïwan] ; Pei-Ni Chen [Taïwan] ; Yi-Hsien Hsieh [Taïwan]

Source :

Journal of pineal research [ 1600-079X ] ; 2020.

RBID : pubmed:31605630

Descripteurs français

KwdFr :
- Agents protecteurs (pharmacologie), Cathepsines (génétique), Cathepsines (métabolisme), Expression des gènes (effets des médicaments et des substances chimiques), Facteur de croissance épidermique (génétique), Facteur de croissance épidermique (métabolisme), Humains (MeSH), Lignée cellulaire (MeSH), Modèles biologiques (MeSH), Mouvement cellulaire (effets des médicaments et des substances chimiques), Mélatonine (pharmacologie), Prolifération cellulaire (effets des médicaments et des substances chimiques), Transduction du signal (effets des médicaments et des substances chimiques), Vitréorétinopathie proliférante (métabolisme), Épithélium pigmentaire de la rétine (cytologie).
MESH :
- cytologie : Épithélium pigmentaire de la rétine.
- effets des médicaments et des substances chimiques : Expression des gènes, Mouvement cellulaire, Prolifération cellulaire, Transduction du signal.
- génétique : Cathepsines, Facteur de croissance épidermique.
- métabolisme : Cathepsines, Facteur de croissance épidermique, Vitréorétinopathie proliférante.
- pharmacologie : Agents protecteurs, Mélatonine.
- Humains, Lignée cellulaire, Modèles biologiques.

English descriptors

KwdEn :
- Cathepsins (genetics), Cathepsins (metabolism), Cell Line (MeSH), Cell Movement (drug effects), Cell Proliferation (drug effects), Epidermal Growth Factor (genetics), Epidermal Growth Factor (metabolism), Gene Expression (drug effects), Humans (MeSH), Melatonin (pharmacology), Models, Biological (MeSH), Protective Agents (pharmacology), Retinal Pigment Epithelium (cytology), Signal Transduction (drug effects), Vitreoretinopathy, Proliferative (metabolism).
MESH :
- chemical , genetics : Cathepsins, Epidermal Growth Factor.
- chemical , metabolism : Cathepsins, Epidermal Growth Factor.
- cytology : Retinal Pigment Epithelium.
- drug effects : Cell Movement, Cell Proliferation, Gene Expression, Signal Transduction.
- metabolism : Vitreoretinopathy, Proliferative.
- chemical , pharmacology : Melatonin, Protective Agents.
- Cell Line, Humans, Models, Biological.

Abstract

Abnormal proliferation and motility of retinal pigment epithelial cells leads to proliferative vitreoretinopathy (PVR). Melatonin is a known effective antitumour and anti-invasive agent, but whether it affects the formation and underlying mechanisms of PVR remains unclear. In this study, the results of the MTT assay, colony formation and propidium iodide (PI) staining with flow cytometry revealed that melatonin dose dependently inhibited epidermal growth factor (EGF)-induced proliferation of human ARPE-19 cells. Furthermore, melatonin reduced EGF-induced motility by suppressing cathepsin S (CTSS) expression. Pretreatment with ZFL (a CTSS inhibitor) or overexpression of CTSS (pCMV-CTSS) significantly inhibited EGF-induced cell motility when combined with melatonin. Epidermal growth factor induced the phosphorylation of AKT(S473)/mTOR (S2448) and transcription factor (c-Jun/Sp1) signaling pathways. Pretreatment of LY294002 (a PI3K inhibitor) or rapamycin (an mTOR inhibitor) markedly reduced EGF-induced motility and p-AKT/p-mTOR/c-Jun/Sp1 expression when combined with melatonin. Taken together, these data indicate that melatonin inhibited EGF-induced proliferation and motility of human ARPE-19 cells by activating the AKT/mTOR pathway, which is dependent on CTSS modulation of c-Jun/Sp1 signalling. Melatonin may be a promising therapeutic drug against PVR.

DOI: 10.1111/jpi.12615
PubMed: 31605630

Affiliations:

Taïwan

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000180
to stream Main, to step Curation: 000180

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.</title>
<author><name sortKey="Yang, Shun Fa" sort="Yang, Shun Fa" uniqKey="Yang S" first="Shun-Fa" last="Yang">Shun-Fa Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Medicine, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Research, Chung Shan Medical University Hospital, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yong Syuan" sort="Chen, Yong Syuan" uniqKey="Chen Y" first="Yong-Syuan" last="Chen">Yong-Syuan Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chien, Hsiang Wen" sort="Chien, Hsiang Wen" uniqKey="Chien H" first="Hsiang-Wen" last="Chien">Hsiang-Wen Chien</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Medicine, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City</wicri:regionArea>
<wicri:noRegion>New Taipei City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Ophthalmology, Cathay General Hospital, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Medicine, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City</wicri:regionArea>
<wicri:noRegion>New Taipei City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Ophthalmology, Cathay General Hospital, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Chia Liang" sort="Lin, Chia Liang" uniqKey="Lin C" first="Chia-Liang" last="Lin">Chia-Liang Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chiou, Hui Ling" sort="Chiou, Hui Ling" uniqKey="Chiou H" first="Hui-Ling" last="Chiou">Hui-Ling Chiou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Chia Yi" sort="Lee, Chia Yi" uniqKey="Lee C" first="Chia-Yi" last="Lee">Chia-Yi Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua</wicri:regionArea>
<wicri:noRegion>Changhua</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Pei Ni" sort="Chen, Pei Ni" uniqKey="Chen P" first="Pei-Ni" last="Chen">Pei-Ni Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsieh, Yi Hsien" sort="Hsieh, Yi Hsien" uniqKey="Hsieh Y" first="Yi-Hsien" last="Hsieh">Yi-Hsien Hsieh</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Clinical laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Clinical laboratory, Chung Shan Medical University Hospital, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:31605630</idno>
<idno type="pmid">31605630</idno>
<idno type="doi">10.1111/jpi.12615</idno>
<idno type="wicri:Area/Main/Corpus">000180</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000180</idno>
<idno type="wicri:Area/Main/Curation">000180</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000180</idno>
<idno type="wicri:Area/Main/Exploration">000180</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.</title>
<author><name sortKey="Yang, Shun Fa" sort="Yang, Shun Fa" uniqKey="Yang S" first="Shun-Fa" last="Yang">Shun-Fa Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Medicine, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Research, Chung Shan Medical University Hospital, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yong Syuan" sort="Chen, Yong Syuan" uniqKey="Chen Y" first="Yong-Syuan" last="Chen">Yong-Syuan Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chien, Hsiang Wen" sort="Chien, Hsiang Wen" uniqKey="Chien H" first="Hsiang-Wen" last="Chien">Hsiang-Wen Chien</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Medicine, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City</wicri:regionArea>
<wicri:noRegion>New Taipei City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Ophthalmology, Cathay General Hospital, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Medicine, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City</wicri:regionArea>
<wicri:noRegion>New Taipei City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Ophthalmology, Cathay General Hospital, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Chia Liang" sort="Lin, Chia Liang" uniqKey="Lin C" first="Chia-Liang" last="Lin">Chia-Liang Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chiou, Hui Ling" sort="Chiou, Hui Ling" uniqKey="Chiou H" first="Hui-Ling" last="Chiou">Hui-Ling Chiou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Chia Yi" sort="Lee, Chia Yi" uniqKey="Lee C" first="Chia-Yi" last="Lee">Chia-Yi Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua</wicri:regionArea>
<wicri:noRegion>Changhua</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Pei Ni" sort="Chen, Pei Ni" uniqKey="Chen P" first="Pei-Ni" last="Chen">Pei-Ni Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsieh, Yi Hsien" sort="Hsieh, Yi Hsien" uniqKey="Hsieh Y" first="Yi-Hsien" last="Hsieh">Yi-Hsien Hsieh</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Clinical laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Clinical laboratory, Chung Shan Medical University Hospital, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of pineal research</title>
<idno type="eISSN">1600-079X</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cathepsins (genetics)</term>
<term>Cathepsins (metabolism)</term>
<term>Cell Line (MeSH)</term>
<term>Cell Movement (drug effects)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Epidermal Growth Factor (genetics)</term>
<term>Epidermal Growth Factor (metabolism)</term>
<term>Gene Expression (drug effects)</term>
<term>Humans (MeSH)</term>
<term>Melatonin (pharmacology)</term>
<term>Models, Biological (MeSH)</term>
<term>Protective Agents (pharmacology)</term>
<term>Retinal Pigment Epithelium (cytology)</term>
<term>Signal Transduction (drug effects)</term>
<term>Vitreoretinopathy, Proliferative (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agents protecteurs (pharmacologie)</term>
<term>Cathepsines (génétique)</term>
<term>Cathepsines (métabolisme)</term>
<term>Expression des gènes (effets des médicaments et des substances chimiques)</term>
<term>Facteur de croissance épidermique (génétique)</term>
<term>Facteur de croissance épidermique (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Modèles biologiques (MeSH)</term>
<term>Mouvement cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Mélatonine (pharmacologie)</term>
<term>Prolifération cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
<term>Vitréorétinopathie proliférante (métabolisme)</term>
<term>Épithélium pigmentaire de la rétine (cytologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cathepsins</term>
<term>Epidermal Growth Factor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cathepsins</term>
<term>Epidermal Growth Factor</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Épithélium pigmentaire de la rétine</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Retinal Pigment Epithelium</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Movement</term>
<term>Cell Proliferation</term>
<term>Gene Expression</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Expression des gènes</term>
<term>Mouvement cellulaire</term>
<term>Prolifération cellulaire</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cathepsines</term>
<term>Facteur de croissance épidermique</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Vitreoretinopathy, Proliferative</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cathepsines</term>
<term>Facteur de croissance épidermique</term>
<term>Vitréorétinopathie proliférante</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents protecteurs</term>
<term>Mélatonine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Melatonin</term>
<term>Protective Agents</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cell Line</term>
<term>Humans</term>
<term>Models, Biological</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Lignée cellulaire</term>
<term>Modèles biologiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abnormal proliferation and motility of retinal pigment epithelial cells leads to proliferative vitreoretinopathy (PVR). Melatonin is a known effective antitumour and anti-invasive agent, but whether it affects the formation and underlying mechanisms of PVR remains unclear. In this study, the results of the MTT assay, colony formation and propidium iodide (PI) staining with flow cytometry revealed that melatonin dose dependently inhibited epidermal growth factor (EGF)-induced proliferation of human ARPE-19 cells. Furthermore, melatonin reduced EGF-induced motility by suppressing cathepsin S (CTSS) expression. Pretreatment with ZFL (a CTSS inhibitor) or overexpression of CTSS (pCMV-CTSS) significantly inhibited EGF-induced cell motility when combined with melatonin. Epidermal growth factor induced the phosphorylation of AKT(S473)/mTOR (S2448) and transcription factor (c-Jun/Sp1) signaling pathways. Pretreatment of LY294002 (a PI3K inhibitor) or rapamycin (an mTOR inhibitor) markedly reduced EGF-induced motility and p-AKT/p-mTOR/c-Jun/Sp1 expression when combined with melatonin. Taken together, these data indicate that melatonin inhibited EGF-induced proliferation and motility of human ARPE-19 cells by activating the AKT/mTOR pathway, which is dependent on CTSS modulation of c-Jun/Sp1 signalling. Melatonin may be a promising therapeutic drug against PVR.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31605630</PMID>
<DateCompleted><Year>2020</Year>
<Month>06</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>06</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-079X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>68</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Journal of pineal research</Title>
<ISOAbbreviation>J Pineal Res</ISOAbbreviation>
</Journal>
<ArticleTitle>Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.</ArticleTitle>
<Pagination><MedlinePgn>e12615</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/jpi.12615</ELocationID>
<Abstract><AbstractText>Abnormal proliferation and motility of retinal pigment epithelial cells leads to proliferative vitreoretinopathy (PVR). Melatonin is a known effective antitumour and anti-invasive agent, but whether it affects the formation and underlying mechanisms of PVR remains unclear. In this study, the results of the MTT assay, colony formation and propidium iodide (PI) staining with flow cytometry revealed that melatonin dose dependently inhibited epidermal growth factor (EGF)-induced proliferation of human ARPE-19 cells. Furthermore, melatonin reduced EGF-induced motility by suppressing cathepsin S (CTSS) expression. Pretreatment with ZFL (a CTSS inhibitor) or overexpression of CTSS (pCMV-CTSS) significantly inhibited EGF-induced cell motility when combined with melatonin. Epidermal growth factor induced the phosphorylation of AKT(S473)/mTOR (S2448) and transcription factor (c-Jun/Sp1) signaling pathways. Pretreatment of LY294002 (a PI3K inhibitor) or rapamycin (an mTOR inhibitor) markedly reduced EGF-induced motility and p-AKT/p-mTOR/c-Jun/Sp1 expression when combined with melatonin. Taken together, these data indicate that melatonin inhibited EGF-induced proliferation and motility of human ARPE-19 cells by activating the AKT/mTOR pathway, which is dependent on CTSS modulation of c-Jun/Sp1 signalling. Melatonin may be a promising therapeutic drug against PVR.</AbstractText>
<CopyrightInformation>© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Shun-Fa</ForeName>
<Initials>SF</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-0365-7927</Identifier>
<AffiliationInfo><Affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yong-Syuan</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chien</LastName>
<ForeName>Hsiang-Wen</ForeName>
<Initials>HW</Initials>
<AffiliationInfo><Affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Kai</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Chia-Liang</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chiou</LastName>
<ForeName>Hui-Ling</ForeName>
<Initials>HL</Initials>
<AffiliationInfo><Affiliation>Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Chia-Yi</ForeName>
<Initials>CY</Initials>
<AffiliationInfo><Affiliation>Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Pei-Ni</ForeName>
<Initials>PN</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsieh</LastName>
<ForeName>Yi-Hsien</ForeName>
<Initials>YH</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-4942-1888</Identifier>
<AffiliationInfo><Affiliation>Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Clinical laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>CSH-2019-E-001-Y3</GrantID>
<Agency>Chung Shan Medical University Hospital</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>11</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Pineal Res</MedlineTA>
<NlmUniqueID>8504412</NlmUniqueID>
<ISSNLinking>0742-3098</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020011">Protective Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>62229-50-9</RegistryNumber>
<NameOfSubstance UI="D004815">Epidermal Growth Factor</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.-</RegistryNumber>
<NameOfSubstance UI="D002403">Cathepsins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.22.27</RegistryNumber>
<NameOfSubstance UI="C028217">cathepsin S</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>JL5DK93RCL</RegistryNumber>
<NameOfSubstance UI="D008550">Melatonin</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D002403" MajorTopicYN="N">Cathepsins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002465" MajorTopicYN="N">Cell Movement</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004815" MajorTopicYN="N">Epidermal Growth Factor</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008550" MajorTopicYN="N">Melatonin</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020011" MajorTopicYN="N">Protective Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055213" MajorTopicYN="N">Retinal Pigment Epithelium</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018630" MajorTopicYN="N">Vitreoretinopathy, Proliferative</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AKT</Keyword>
<Keyword MajorTopicYN="N">Sp1</Keyword>
<Keyword MajorTopicYN="N">c-Jun</Keyword>
<Keyword MajorTopicYN="N">cathepsin S</Keyword>
<Keyword MajorTopicYN="N">epidermal growth factor</Keyword>
<Keyword MajorTopicYN="N">mTOR</Keyword>
<Keyword MajorTopicYN="N">melatonin</Keyword>
<Keyword MajorTopicYN="N">motility</Keyword>
<Keyword MajorTopicYN="N">proliferation</Keyword>
<Keyword MajorTopicYN="N">retinal pigment epithelial cells</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>06</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>09</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>10</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>10</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>6</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>10</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31605630</ArticleId>
<ArticleId IdType="doi">10.1111/jpi.12615</ArticleId>
</ArticleIdList>
<ReferenceList><Title>REFERENCES</Title>
<Reference><Citation>Garweg JG, Tappeiner C, Halberstadt M. Pathophysiology of proliferative vitreoretinopathy in retinal detachment. Surv Ophthalmol. 2013;58(4):321-329.</Citation>
</Reference>
<Reference><Citation>Ducournau Y, Boscher C, Adelman RA, et al. Proliferation of the ciliary epithelium with retinal neuronal and photoreceptor cell differentiation in human eyes with retinal detachment and proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol. 2012;250(3):409-423.</Citation>
</Reference>
<Reference><Citation>Dithmer M, Fuchs S, Shi Y, et al. Fucoidan reduces secretion and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces angiogenesis in vitro. PLoS ONE. 2014;9(2):e89150.</Citation>
</Reference>
<Reference><Citation>Cipolla-Neto J, Amaral FGD. Melatonin as a hormone: new physiological and clinical insights. Endocr Rev. 2018;39(6):990-1028.</Citation>
</Reference>
<Reference><Citation>Zhou H, Li D, Zhu P, et al. Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury. J Pineal Res. 2018;65(3):e12503.</Citation>
</Reference>
<Reference><Citation>Gao J, Xu K, Liu H, et al. Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism. Front Cell Infect Microbiol. 2018;8:13.</Citation>
</Reference>
<Reference><Citation>El-Sokkary GH, Ismail IA, Saber SH. Melatonin inhibits breast cancer cell invasion through modulating DJ-1/KLF17/ID-1 signaling pathway. J Cell Biochem. 2019;120(3):3945-3957.</Citation>
</Reference>
<Reference><Citation>Shen YQ, Guerra-Librero A, Fernandez-Gil BI, et al. Combination of melatonin and rapamycin for head and neck cancer therapy: suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. J Pineal Res. 2018;64(3):e12461.</Citation>
</Reference>
<Reference><Citation>Lin S, Hoffmann K, Gao C, Petrulionis M, Herr I, Schemmer P. Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma. J Pineal Res. 2017;62(3):e12398.</Citation>
</Reference>
<Reference><Citation>Yu HS, Hernandez V, Haywood M, Wong CG. Melatonin inhibits the proliferation of retinal pigment epithelial (RPE) cells in vitro. Vitro Cell Dev Biol Anim. 1993;29A(5):415-418.</Citation>
</Reference>
<Reference><Citation>Liang FQ, Green L, Wang C, Alssadi R, Godley BF. Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stress. Exp Eye Res. 2004;78(6):1069-1075.</Citation>
</Reference>
<Reference><Citation>Yan G, Yu L, Jiang S, Zhu J. Melatonin antagonizes oxidative stress-induced mitochondrial dysfunction in retinal pigmented epithelium cells via melatonin receptor 1 (MT1). J Toxicol Sci. 2018;43(11):659-669.</Citation>
</Reference>
<Reference><Citation>Chang CC, Huang TY, Chen HY, et al. Protective effect of melatonin against oxidative stress-induced apoptosis and enhanced autophagy in human retinal pigment epithelium cells. Oxid Med Cell Longev. 2018;2018:9015765.</Citation>
</Reference>
<Reference><Citation>Steindl-Kuscher K, Boulton ME, Haas P, Dossenbach-Glaninger A, Feichtinger H, Binder S. Epidermal growth factor: the driving force in initiation of RPE cell proliferation. Graefes Arch Clin Exp Ophthalmol. 2011;249(8):1195-1200.</Citation>
</Reference>
<Reference><Citation>Zhang L, Wang H, Xu J. Cathepsin S as a cancer target. Neoplasma. 2015;62(1):16-26.</Citation>
</Reference>
<Reference><Citation>Kos J, Sekirnik A, Kopitar G, et al. Cathepsin S in tumours, regional lymph nodes and sera of patients with lung cancer: relation to prognosis. Br J Cancer. 2001;85(8):1193-1200.</Citation>
</Reference>
<Reference><Citation>Zhang L, Wang H, Xu J, Zhu J, Ding K. Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways. Toxicol Lett. 2014;228(3):248-259.</Citation>
</Reference>
<Reference><Citation>Akkari L, Gocheva V, Quick ML, et al. Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes Dev. 2016;30(2):220-232.</Citation>
</Reference>
<Reference><Citation>Hou WS, Li W, Keyszer G, et al. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002;46(3):663-674.</Citation>
</Reference>
<Reference><Citation>Haves-Zburof D, Paperna T, Gour-Lavie A, Mandel I, Glass-Marmor L, Miller A. Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis. J Cell Mol Med. 2011;15(11):2421-2429.</Citation>
</Reference>
<Reference><Citation>Nakajima T, Nakamura H, Owen CA, et al. Plasma Cathepsin S and Cathepsin S/Cystatin C ratios are potential biomarkers for COPD. Dis Markers. 2016;2016:4093870.</Citation>
</Reference>
<Reference><Citation>Edman MC, Janga SR, Meng Z, et al. Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjogren's Syndrome patients. Sci Rep. 2018;8(1):11044.</Citation>
</Reference>
<Reference><Citation>Klinngam W, Fu R, Janga SR, Edman MC, Hamm-Alvarez SF. Cathepsin S Alters the expression of pro-inflammatory cytokines and MMP-9, partially through protease-activated receptor-2, in human corneal epithelial cells. Int J Mol Sci. 2018;19(11):3530.</Citation>
</Reference>
<Reference><Citation>Nakagawa TY, Brissette WH, Lira PD, et al. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity. 1999;10(2):207-217.</Citation>
</Reference>
<Reference><Citation>Saegusa K, Ishimaru N, Yanagi K, et al. Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity. J Clin Invest. 2002;110(3):361-369.</Citation>
</Reference>
<Reference><Citation>Chaum E, Yin J, Yang H, Thomas F, Lang JC. Quantitative AP-1 gene regulation by oxidative stress in the human retinal pigment epithelium. J Cell Biochem. 2009;108(6):1280-1291.</Citation>
</Reference>
<Reference><Citation>Lin HY, Chen YS, Wang K, Chien HW, Hsieh YH, Yang SF. Fisetin inhibits epidermal growth factor-induced migration of ARPE-19 cells by suppression of AKT activation and Sp1-dependent MMP-9 expression. Mol Vis. 2017;23:900-910.</Citation>
</Reference>
<Reference><Citation>Li H, Zhang B, Liu Y, Yin C. EBP50 inhibits the migration and invasion of human breast cancer cells via LIMK/cofilin and the PI3K/Akt/mTOR/MMP signaling pathway. Med Oncol. 2014;31(9):162.</Citation>
</Reference>
<Reference><Citation>Pasquale LR, Borras T, Fingert JH, Wiggs JL, Ritch R. Exfoliation syndrome: assembling the puzzle pieces. Acta Ophthalmol. 2016;94(6):e505-512.</Citation>
</Reference>
<Reference><Citation>Bardak H, Uguz AC, Bardak Y. Protective effects of melatonin and memantine in human retinal pigment epithelium (ARPE-19) cells against 2-ethylpyridine-induced oxidative stress: implications for age-related macular degeneration. Cutan Ocul Toxicol. 2018;37(2):112-120.</Citation>
</Reference>
<Reference><Citation>Bondy SC, Campbell A. Mechanisms underlying tumor suppressive properties of melatonin. Int J Mol Sci. 2018;19(8):2205.</Citation>
</Reference>
<Reference><Citation>Reiter RJ, Tan DX, Galano A. Melatonin: exceeding expectations. Physiology. 2014;29(5):325-333.</Citation>
</Reference>
<Reference><Citation>Wu MH, Lin CL, Chiou HL, et al. Praeruptorin A inhibits human cervical cancer cell growth and invasion by suppressing MMP-2 expression and ERK1/2 Signaling. Int J Mol Sci. 2017;19(1):10.</Citation>
</Reference>
<Reference><Citation>Shi GP, Webb AC, Foster KE, et al. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994;269(15):11530-11536.</Citation>
</Reference>
<Reference><Citation>Xu J, Wang H, Ding K, et al. Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice. Mediators Inflamm. 2013;2013:187873.</Citation>
</Reference>
<Reference><Citation>Kumar Vr S, Darisipudi MN, Steiger S, et al. Cathepsin S cleavage of protease-activated receptor-2 on endothelial cells promotes microvascular diabetes complications. J Am Soc Nephrol. 2016;27(6):1635-1649.</Citation>
</Reference>
<Reference><Citation>Seo BR, Min KJ, Woo SM, et al. Inhibition of Cathepsin S induces mitochondrial ROS that sensitizes TRAIL-mediated apoptosis through p53-mediated downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27(4):215-233.</Citation>
</Reference>
<Reference><Citation>Seo SU, Woo SM, Min KJ, Kwon TK. Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-induced apoptosis through upregulation of Bim expression. Biochem Biophys Res Commun. 2018;498(4):849-854.</Citation>
</Reference>
<Reference><Citation>Gautam J, Banskota S, Lee H, et al. Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis. Exp Mol Med. 2018;50(9):118.</Citation>
</Reference>
<Reference><Citation>Stellos K, Gatsiou A, Stamatelopoulos K, et al. Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med. 2016;22(10):1140-1150.</Citation>
</Reference>
<Reference><Citation>Molis TM, Spriggs LL, Jupiter Y, Hill SM. Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer. J Pineal Res. 1995;18(2):93-103.</Citation>
</Reference>
<Reference><Citation>Guillaumond F, Sage D, Deprez P, Bosler O, Becquet D, Francois-Bellan AM. Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers. J Neurochem. 2000;75(4):1398-1407.</Citation>
</Reference>
<Reference><Citation>Chetsawang B, Govitrapong P, Ebadi M. The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells. Neurosci Lett. 2004;371(2-3):205-208.</Citation>
</Reference>
<Reference><Citation>Chiang GG, Abraham RT. Targeting the mTOR signaling network in cancer. Trends Mol Med. 2007;13(10):433-442.</Citation>
</Reference>
<Reference><Citation>Zhao C, Yasumura D, Li X, et al. mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. J Clin Invest. 2011;121(1):369-383.</Citation>
</Reference>
<Reference><Citation>Chen H, Wang H, An J, Shang Q, Ma J. Plumbagin induces RPE cell cycle arrest and apoptosis via p38 MARK and PI3K/AKT/mTOR signaling pathways in PVR. BMC Complement Altern Med. 2018;18(1):89.</Citation>
</Reference>
<Reference><Citation>Liegl R, Koenig S, Siedlecki J, Haritoglou C, Kampik A, Kernt M. Temsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expression. PLoS ONE. 2014;9(2):e88203.</Citation>
</Reference>
<Reference><Citation>Lin C, Chao H, Li Z, et al. Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy. J Pineal Res. 2016;61(2):177-186.</Citation>
</Reference>
<Reference><Citation>Yang L, Zhang Y, Ma Y, et al. Effect of melatonin on EGF- and VEGF-induced monolayer permeability of HUVECs. Am J Physiol Heart Circ Physiol. 2019;316(5):H1178-H1191.</Citation>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Yang, Shun Fa" sort="Yang, Shun Fa" uniqKey="Yang S" first="Shun-Fa" last="Yang">Shun-Fa Yang</name>
</noRegion>
<name sortKey="Chen, Pei Ni" sort="Chen, Pei Ni" uniqKey="Chen P" first="Pei-Ni" last="Chen">Pei-Ni Chen</name>
<name sortKey="Chen, Yong Syuan" sort="Chen, Yong Syuan" uniqKey="Chen Y" first="Yong-Syuan" last="Chen">Yong-Syuan Chen</name>
<name sortKey="Chien, Hsiang Wen" sort="Chien, Hsiang Wen" uniqKey="Chien H" first="Hsiang-Wen" last="Chien">Hsiang-Wen Chien</name>
<name sortKey="Chien, Hsiang Wen" sort="Chien, Hsiang Wen" uniqKey="Chien H" first="Hsiang-Wen" last="Chien">Hsiang-Wen Chien</name>
<name sortKey="Chien, Hsiang Wen" sort="Chien, Hsiang Wen" uniqKey="Chien H" first="Hsiang-Wen" last="Chien">Hsiang-Wen Chien</name>
<name sortKey="Chiou, Hui Ling" sort="Chiou, Hui Ling" uniqKey="Chiou H" first="Hui-Ling" last="Chiou">Hui-Ling Chiou</name>
<name sortKey="Hsieh, Yi Hsien" sort="Hsieh, Yi Hsien" uniqKey="Hsieh Y" first="Yi-Hsien" last="Hsieh">Yi-Hsien Hsieh</name>
<name sortKey="Hsieh, Yi Hsien" sort="Hsieh, Yi Hsien" uniqKey="Hsieh Y" first="Yi-Hsien" last="Hsieh">Yi-Hsien Hsieh</name>
<name sortKey="Hsieh, Yi Hsien" sort="Hsieh, Yi Hsien" uniqKey="Hsieh Y" first="Yi-Hsien" last="Hsieh">Yi-Hsien Hsieh</name>
<name sortKey="Lee, Chia Yi" sort="Lee, Chia Yi" uniqKey="Lee C" first="Chia-Yi" last="Lee">Chia-Yi Lee</name>
<name sortKey="Lin, Chia Liang" sort="Lin, Chia Liang" uniqKey="Lin C" first="Chia-Liang" last="Lin">Chia-Liang Lin</name>
<name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name>
<name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name>
<name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name>
<name sortKey="Yang, Shun Fa" sort="Yang, Shun Fa" uniqKey="Yang S" first="Shun-Fa" last="Yang">Shun-Fa Yang</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000089 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000089 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:31605630
   |texte=   Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:31605630" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.

Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki